We don't live in a flood or wildfire zone, and there are no factories or major roads nearby that might be a hazmat problem. For most situations our plan is to "bunker up" and wait out any problems. We have water, food, and other supplies to last a couple of weeks. Leaving would be "Plan B."
Our main problems are health-related. My wife takes half a dozen meds for some serious conditions. She'd probably make it a few weeks without them before she packed it in. She gets samples from her doctor and we store them in the freezer, rotating stock from oldest to newest, since our insurance keeps us on a 30-day leash. We've been extending our supplies slowly. My problems are less severe, but neither one of us is going to make it long out in the woods, so most of our scenarios involve staying near any possible medical care.
Other than that, we don't have a single bug-out bag. Instead, we have a large bookcase near the door, with various bags in it - our overnight bags, prepacked in case we go somewhere, my motorcycle tailbag, which has maps and a medical kit, spare cellphone charger, several flashlights including one with both 115v and 12v chargers, power inverter, spare CPAP machine, small supplies of water and food. Elsewhere, we have meds, fireproof box with important papers, firearms, tools, etc. We have the bags graded in order of importance; load up in order as time and space permit, then boogie.
I've been working on scanning important papers - deeds, insurance papers, NFA documents, medical files, address books, etc. - into .jpgs to store on the USB key that always rides in my watch pocket.