We have several bags on a large shelf by the front door. One has my spare CPAP machine, a couple of extension cords, and a DC/AC power convertor. (there's a ziplock with other meds in the refrigerator)
One "overnight bag" for each of us - socks, underwear, clean shirt, toothbrush and paste, slippers, etc. They get used a couple of times a year, when we spend the night somewhere else.
One bag with a pistol, a couple of spare magazines, some money, spare credit cards, a CD and a USB key containing digitized documents (insurance papers, copies of titles and deeds, a few medical records, etc.).
One bag for some canned food. I need to expand the supply a bit.
Our tap water has the chlorine content of a public pool, so I drink (cheap) bottled water. The water gets stored in the shelf, since the cases are heavy and neither one of us wants to lug them further into the house. I figure I can toss a case into the car if needed.
Both of us are just shy of disabled, so all of our plans involve motorized transportation if we leave the house. Our basic plan is to stay indoors and ride out whatever happens; the main "go" scenario involves "a tornado is here."