Well, as your wife sez ya got 2 hands so you should always buy 2 of whatever handgun you get. Remind her it was her idea.
First off, you need a good .22 target grade pistol for practice and small game hunting. Easy to suppress too, if ya get the type with interchangeable bbls the integrally suppressed spare bbls will be an easy swap. Great survival gun too, lots of ammo with little weight.
Next, ya need a few good self defense pistols, full size and a compact model for varying modes of dress and threat level. Caliber of your choice. A backup too, something small you can easily conceal.
Then ya need a good hunting pistol for various sized game. A .357 revolver is about the min for taking deer sized game, a .44 if ya expect them to be larger. A good TC Contender with a few different bbls could also fill the bill, especially if ya get them in rifle calibers you already stock.
You also need a realy small deep cover hideout piece, something so small you can disappear it into a pocket. Easily missed in a hasty search.
Ya also need a good "throwdown" piece so you can arm the unarmed a**holes before ya blast them. Some people prefer a knife for this purpose as it can be easily carried in a pocket wrapped in a hanky. I however think a good small saturday night special in broken condition would be the ideal tool for the job, menacing enough it warrants
deadly force, yet safe because it doesn't go bang. Just toss it to them, most people catch without thinking.
Finally, ya need a shower gun, a nice all stainless steel piece to keep in the shower for bathroom emergencies. Ya saw Psycho, right?